Requests for reprints: Makoto Mark Taketo, Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo, Kyoto 606-8501, Japan. Phone: 81-75-753-4391; Fax: 81-75-753-4402; E-mail: taketo I2005 American Association for Cancer Research. doi: 10.1158 0008-5472 N-05-1936.
A structured training programme on the basics of psychiatric research was initiated in the year 2005 for the medical officers and registrars at the Institute of Mental Health, Singapore. The objectives were to encourage young doctors to appreciate the value of clinical research; and to teach them the basics of doing research, presenting the findings and writing for publication. The topics covered under the training series were: Ethical issues in psychiatric research, obtaining informed consent and overview of the IRB process Writing a grant paper Discussion and critique of research protocols Types of study design: case series, open trials, randomised controlled trials, and epidemiology studies Basic Biostatistics: understanding power calculation Overview of basic and intermediate biostatistics: Psychiatric rating scales How to critically appraise a paper, because avalide avapro.

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WHN primary care providers, as part of the Regional Delivery Network of West Michigan RDN ; , have been selected by BCBS for a pharmacy pilot program. What's being reviewed? Our trend in increased pharmacy cost compared to the rest of West Michigan. No risk??? Unlike many programs, there is no penalty to our practitioners with this program if they do not meet the target goal. If our costs rise at a higher rate than the estimate, we lose nothing. What is the benefit? $$$. If our pharmacy costs rise at a lower rate than our control group, a financial benefit will be sent to the RDN to distribute to the various PHOs. Westshore Health Network has opted to not utilize the benefit for administrative costs, but to pass any dollars on directly to our practitioners. What is expected of WHN PCPs? 1. If Mike Strampel, RPh calls to schedule a meeting with your office, it is to your benefit to do so. Mike has been visiting as many PCP offices as he can schedule to provide prescriber-specific data with simple changes that can optimize patient care & costs. For example, . 2. Mike has & will be mailing dose optimization reports: Common medications where multiple tablet doses are being prescribed when a higher dose tablet is available. By making these changes in the # of tablets or from BID to QD, you will not only reduce cost, but increase the likelihood of patient compliance. Examples: Lipitor 20 mg 2 tabs qHS - use Lipitor 40 mg tab qHS Prozac 20 mg 2 tabs BID - use Prozac 40 mg 2 tabs QD Did you know the following tablet capsule strengths are available and can be given as ONCE DAILY doses with equal or greater efficacy than multiple daily doses ; ? Avxpro 300 mg Lescol 40 mg Prilosec 40 mg Bextra 20 mg Lipitor 40 mg, 80 mg Prinivil Zestril 10 mg, 20 mg, 40 mg Celebrex 200 mg Mavik 2 mg Prozac 20 mg, 40 mg Celexa 40 mg Norvasc 10 mg Toprol XL 50 mg, 100 mg, 200 mg Cozaar 50 mg, 100 mg Paxil 20 mg, 30 mg, 40 mg Vioxx 25 mg, 50 mg Diovan 160mg, 320 mg Plendil 5 mg, 10 mg Zocor 80 mg Effexor-XR 75mg, 150mg Pravachol 80 mg Zoloft 50 mg, 100 mg. Prescription vitamins and mineral products, except prenatal vitamins and fluoride preparations--the list of drugs can be found on the web at HOPbenefits . Barbiturates--see list beginning on page 13 Benzodiazepines--see list beginning on page 13.

Since the 1950's effective drug treatments have revolutionised the management of many psychiatric disorders. However, there is no such thing as a "miracle cure" and the use of drugs in psychiatry requires psychological as well as pharmacological skills. Because of the sensitivity and complexity of the central nervous system interactions and adverse effects with psychotropic i.e. psychologically active ; drugs are common. The pharmacokinetics and pharmacodynamics of these compounds must therefore be understood. It is not obvious to patients that drugs can improve their psychological difficulties, especially if insight is impaired, and steps to encourage compliance are vital. Psychosocial effects of taking medication may be positive e.g. placebo effect ; or negative e.g. less motivation in psychotherapy because tablets are seen as a panacea ; . Medication is often just one component of a treatment plan that also includes psychosocial therapies. The place of drugs in this combined approach should be explained to the patient. Compliance is increased by attention to the following: Empathy: the patient feels understood. Education: about the diagnosis and its implications. Explanation: about the drug, its intended action and the likely adverse effect. Efficiency: simplify the drug regime as much as possible and avoid polypharmacy.

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