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Armand, J.P., Extra, Y.M., Catimel, G., Abigerges, D., Marty, M., and Clavel, M. 1996 ; Rationale for the dosage and schedule of CPT-11 irinotecan ; selected for phase II studies, as determined by European phase I studies. Ann. Oncol. 7, 837 842. Bleiberg, H., and Cvitkovic, E. 1996 ; Characterisation and clinical management of CPT-11 irinotecan ; -induced adverse events: The European perspective. Eur. J. Cancer. 32A, S18 S23. CBTRUS. Central Brain Tumor Registry of the United States 2002 ; . Statistical Report: Primary Brain Tumors in the United States, 1995 1999. Chicago: Central Brain Tumor Registry of the United States available at : cbtrus 2002 2002report ; . Cloughesy, T., Filka, E., Friedman, H., Kabbinavar, F., Kuhn, J., Selch, M., and Miller, L. 2000 ; A phase I intrapatient dose escalation ; open-label study of irinotecan CPT-11 ; in patients with recurrent or progressive malignant glioma. Proc. Am. Soc. Clin. Oncol. 19, 161a abstract ; . Coggins, C.A., Elion, G.B., Houghton, P.J., Hare, C.B., Keir, S., Colvin, O.M., Bigner, D.D., and Friedman, H.S. 1998 ; Enhancement of irinotecan CPT-11 ; activity against central nervous system tumor xenografts by alkylating agents. Cancer Chemother. Pharmacol. 41, 485 490. Colvin, O.M., Cokgor, I., Edwards, S., Albergo, G., Tourt-Uhlig, S., Rich, J.N., Quinn, J.A., Stewart, B., McLendon, R.E., Provenzale, J.M., Sampson, J.H., Haglund, M.M. [and Beason, R., Miller, L., Zaknoen, S., Fraass, U., Dugan, M., Bigner, D., Stafford-Fox, V., Cohen, L., Friedman, A., and Friedman, H.] 2000 ; Phase I trials of Gliadel plus CPT-11 or Temodar. Proc. Am. Soc. Clin. Oncol. 19, 172a. Abstract ; Conrad, C.A., Milosavljevic, V.P., and Yung, W.K. 1995 ; Advances in chemotherapy for brain tumors. Neurol. Clin. 13, 795 812. Fetell, M.R., Grossman, S.A., Fisher, J.D., Erlanger, B., Rowinsky, E., Stockel, J., and Piantadosi, S. 1997 ; Preirradiation paclitaxel in glioblastoma multiforme: Efficacy, pharmacology and drug interactions. New Approaches to Brain Tumor Therapy Central Nervous System Consortium. J. Clin. Oncol. 15, 3121 3128. Fine, H.A., Dear, K.B., Loeffler, J.S., Black, P.M., and Canellos, G.P. 1993 ; Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71, 2585 2597. Friedman, A.H., Quinn, J.A., Tourt-Uhlig, S., Rich, J.N., Stewart, E.S., Affronti, M.L., Provenzale, J., McLendon, R., Gururangan, S., Buchanan, W., Colvin, O.M., Bigner, D.D., Beason, R., Sampson, J., Haglund, M., Miller, L., and Friedman, H.S. 2001 ; Phase I trial of CPT-11 plus BCNU in malignant glioma. Proc. Am. Soc. Clin. Oncol. 20, 64a abstract ; . Friedman, H.S., Petros, W.P., Friedman, A.H., Schaaf, L.J., Kerby, T., Lawyer, J., Parry, M., Houghton, P.J., Lovell, S., Rasheed, K., Cloughesy, T. Stewart, E.S., Colvin, O.M., Provenzale, J.M., McLendon, R.E., Bigner, D.D., Cokgor, I., Haglund, M., Rich, J., Ashley, D., Malczyn, J., Elfring, G.L., and Miller, L.L. 1999 ; Irinotecan therapy in adults with recurrent or progressive malignant glioma. J. Clin. Oncol. 17, 1516 1525. Gilbert, M.R., Supko, J.G., Batchelor, T., Lesser, G., Fisher, J.D., Piantadosi, S., and Grossman, S. 2003 ; Phase I clinical trial and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma. Clin. Cancer Res. 9, 2940 2949 and gliclazide. Corticosteroids EENT ; dexamethasone sod Devadron ; phosphate flunisolide Nasalide ; fluorometholone Fml ; fluticasone propionate Flonase ; LOTEMAX NASONEX prednisolone acetate Pred Forte ; prednisolone sod Inflamase Forte ; phosphate Eent Anti-inflammatory Agents, Misc. RESTASIS Eent Nonsteroidal Anti-inflam. Agents ACULAR ACULAR LS ACULAR PF flurbiprofen sodium Ocufen ; 1 drops; 0.1% spray drops susp spray; 50mcg drops susp spray; 50mcg drops susp; 1% drops; 1. ADHD subtype: 58% mixed; 2% hyperactive impulsive; 41% inattentive Additional Information Previous medication: All patients followed a min 5 day medication-free evaluation period before randomisation. Ninety-four of the children reported having been previously treated with a stimulant. Concurrent medication: Participants in the trial were not to receive ongoing psychoactive medications other than the study drug and dibenzyline.
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I happy to present our donors with the results of AFA's first annual audit conducted by a Certified Public Accountant. Fortunately, the agency can demonstrate a much-improved financial picture for 2004, following a very difficult fundraising experience in 2003. AFA ended the year with net cash receipts excluding donated medicines and medical supplies ; of $352, 271 and operating expenses excluding distribution of medicine and medical supplies and depreciation but including event expenses ; of $297, 412. This result essentially erased a $41, 500 unaudited ; operating deficit at the end of 2003. Nevertheless, the agency remained in a precarious financial position, with virtually no cash reserve on which to rely should income again fall short of expenses in future periods. Fortunately, AFA conducted a successful fundraiser to coincide with the Art Basel Miami fair in the last month of the year, most of the revenues from which were paid in early January 2005. We can report on a number of financial achievements for 2004. Gross income during the year rose 143% over 2003, largely due to substantially increased benefit event receipts. 2004 marks a period when AFA began a concerted effort to expand and diversify our sources of support in order to promote greater stability. This effort clearly produced meaningful results and we expect our new direct mail appeal, Campaign for Life, to produce similar results as it grows in its reach to new donors. Expenses also rose significantly during the same period, up 51% from $197, 000 unaudited ; in 2003. While some of these expenses were incurred to launch new programs, such as the PFA initiative and the technical assistance service to train treatment advocates, a large proportion of the increased costs resulted from the expansion of our pre-existing services and to develop the Campaign for Life. In addition, event expenses rose by 140% in 2004, reflecting a more ambitious fundraising program. Even so, AFA was able to hold administrative costs to just 20% of our overall expenses, ensuring that most of the funds raised were used to support programmatic efforts. Particular attention to Note 1 of the audit helps explain the agency's true financial condition. Although AFA shows assets of approximately $1.55 million, nearly all of these assets are in the form of donated medications. These drugs cannot be sold and therefore have no redeemable monetary value. Their true worth is, of course, incalculable because they will ultimately save so many lives. The critical nature of AFA's work makes it imperative that the agency build a cash reserve to ensure that medication collection, processing, and shipping can continue uninterrupted regardless of temporary revenue shortfalls. The fact that we do not currently have such a reserve naturally concerns us greatly. 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