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A long list of negative side effects, including a decrease in the ability of the blood to clot. Furthermore, animal studies have shown the drug to cause intestinal cancer. Also, this and other drugs have been linked to depressive illnesses, sexual dysfunction, skin rashes and digestive problems. Many doctors are now questioning the need for such widespread cholesterol-lowering "therapy, " noting that the level can be lowered too much, increasing the risk of cancer. Unfortunately, since most medical schools do not provide adequate training in nutrition, M.D.s usually are unable to address the problem from that angle. They are taught to prescribe drugs or perform surgery and, as a result, that's the only thing many of them recommend. As a result, prescriptions for cholesterol lowering drugs in some areas increased six-fold between 1986 and 1992. SOURCES: British Medical Journal, May 22, 1993 v306 n6889 p1355 2 ; . "The problem with cholesterol: no light at the end of this tunnel?" Editorial by Journal staff ; . British Medical Journal, May 22, 1993 v306 n6889 p1367 7 ; . "Cholesterol lowering and mortality: the importance of considering initial level of risk." The Lancet, March 21, 1992 v339 n8795 p727 3 ; . "Low serum cholesterol and suicide." Patient Care, March 15, 1996 v30 n5 p61 9 ; . "Does reducing cholesterol improve CAD survival?" Includes related article on chances that lipid-lowering drugs may cause cancer. Cancer Biotechnology Weekly, Jan. 15, 1996 p15 3 ; .21 "Cancer risk warned from using cholesterol-lowering drugs." American Medical News, Jan. 8, 1996 v39 n2 p56 1 ; . "Cholesterol drugs tied to cancer in rats; link questioned." The Journal of the American Medical Association, Jan. 3, 1996 v275 n1 p67 3 ; . "Does lowering cholesterol cause cancer?.
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Atkinson HC, Begg EJ. Prediction of dmg concentrations in human skim m l from ik plasma protein binding and acid-base characteristics. British Journal of Clinical Phmacology l988; 25: 496-503. Atkinson HC, Begg W. Prediction of drug distribution into human milk from physicochemical characteristics. Clinical Pharmacokinetics 1990; 18: 151.
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MECHANISM OF ACTION AND PHARMACOKINETICS Irinotecan is a semi-synthetic derivative of camptothecin, an alkaloid extract from camptotheca acuminate. Camptothecin and its analogue belong to the class of Topoisomerase I inhibitors. Topoisomerase I is a DNA enzyme responsible for controlling and modifying DNA during replication and translation of genetic materials. Irinotecan and its active metabolite, SN-38, bind to the topoisomerase DNA complex, preventing religation of the single-strand breaks in the DNA molecule. The drug and its active metabolite are believed to exert their cytotoxic effects during the S-phase of cell cycle.
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Berndt, E. and W. Crown. "Labor Force Activity in Cancer Patients with Anemia." Quality of Life in Oncology 5 4 ; 2002 ; : 1013. Berndt, E.R., A. Bir, S.H. Busch, R.G. Frank, and S.L. Normand. "The Medical Treatment of Depression, 19911996: Productive Inefficiency, Expected Outcome Variations, and Price Indexes." Journal of Health Economics 21 3 ; 2002 ; : 373396. Crown, W.H., S. Finkelstein, E.R. Berndt, D. Ling, A.W. Poret, A.J. Rush, and J.M. Russell. "The Impact of Treatment-Resistant Depression on Health Care Utilization and Costs." Journal of Clinical Psychiatry 63 11 ; 2002 ; : 963971. Crystal-Peters, J., C. Neslusan, W.H. Crown, and A. Torres. "Treating Allergic Rhinitis in Patients with Comorbid Asthma: The Risk of Asthma Related Hospitalizations and Emergency Room Visits." The Journal of Allergy and Clinical Immunology 109 1 ; 2002 ; : 5762. Crystal-Peters, J., C.A. Neslusan, M.W. Smith, and A. Togias. "Health Care Costs of Allergic RhinitisAssociated Conditions Vary with Allergy Season." Annals of Allergy, Asthma & Immunology 89 5 ; 2002 ; : 457462. Crystal-Peters, J., S. Chang, S. Long, and R. Tretiak. "Health Care Expenditures of Patients with Major Depressive Disorder and Post Traumatic Stress Disorder." Eur Psychiatry 17 Suppl 1 2002 ; : 150. Javitz, H.S., M.M. Ward, E. Farber, L. Nail, and S.G. Vallow. "The Direct Cost of Care for Psoriasis and Psoriatic Arthritis in the United States." Journal of the American Academy of Dermatology 46 6 ; 2002 ; : 850860. Poret, A.W., R.J. Ozminkowski, R. Goetzel, J.E. Pew, and J. Balent. "Cost Burden of Illness for Hepatitis C Patients with Employer-Sponsored Health Insurance." Disease Management 5 2 ; 2002 ; : 95107.
FAZACLO . fentanyl patches . fexofenadine . FLAGYL . metronidazole flecainide . FLeXeRIL . See cyclobenzaprine FLOMAX . FLONASe . FLORINeF . See fludrocortisone acetate FLOveNT HFA . FLOveNT ROTADISK . FLOXIN OTIC . fluconazole . fludrocortisone acetate . FLUMADINe . rimantadine fluocinolone acetonide . fluocinonide . FLUOR-OP See fluorometholone fluorometholone . fluorouracil . fluoxetine fluphenazine . FORADIL . FOSAMAX fosinopril . furosemide . FUZeON . gabapentin . ganciclovir . gemfibrozil gentamicin GeODON . 10, 11 GLeeveC . glipizide . glipizide eR GLUCAGON KIT . GLUCATROL . See glipizide GLUCATROL XL See glipizide eR GLUCOPHAGe See metformin GLUCOPHAGe XR See metformin eR GLUCOvANCe glyburide metformin glyburide . glyburide metformin and glucophage.
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35. Kustrin, S. A.; Zivanovic, L.; Radulovic, D.; Vasiljevic, M.; Analyst 1991, 116, 753. Kustrin S. A.; Zivanovic, Lj.; Zecevic, M.; Radulovic, D.; J. Pharm. Biomed. Anal. 1997, 16, 147. de Micalizzi, Y. C.; Pappano, N. B.; Debattista, N. B.; Talanta 1998, 47, 525. El-Didamony, A.M.; Amin, A.S.; Anal. Lett. 2004, 37, 1151. Tubino, M.; de Souza, R.L.; J. AOAC Inter. 2005, 88 in press. 40. Tubino, M.; de Souza, R.L.; Talanta, 2005, in press. 41. Tubino, M.; de Souza, R.L.; 26 th Annual Meeting of the Brazilian Chemical Society, Poos de Caldas, Brasil, 2003. 42. Farmacopia Brasileira, 4. Ed., 2002, parte II, Terceiro Fascculo, p.1218. 43. The United States Pharmacopoeia, USP 25, 25th ed., Webcom Limited, Rochville, 2002, p. 1683. 44. Eckschlager, K.; Errors, Measurement and Results in Chemical Analysis, Van Nostrand Reinhold Company: London, 1972, pp. 109-113. 45. Shabir, A.G.; J. Chromatogr. A 2003, 987, 57. Received: January 12, 2005 Published on the web: August 9, 2005 and glucotrol.
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OPHTHALMIC, cont'd ALPHAGAN P AZOPT BETIMOL BETOPTIC-S TRAVATAN TRAVATAN Z TRUSOPT XALATAN Other Eye Products ACULAR ACULAR LS OPTIVAR PATANOL TOBRADEX VOLTAREN ZYLET PAIN ARTHRITIS Anti-inflammatory Agents diclofenac etodolac ibuprofen indomethacin meloxicam nabumetone naproxen oxaprozin sulindac CELEBREX ENBREL RESPIRATORY Allergy Drugs All generically available antihistamine decongestant combinations that require a prescription are on the formulary. fexofenadine flunisolide fluticasone ALLEGRA-D 12HR, 24HR ASTELIN NASACORT AQ NASONEX Asthma Drugs albuterol inhaler ADVAIR DISKUS ADVAIR HFA FLOVENT HFA FORADIL AEROLIZER INTAL PULMICORT QVAR SEREVENT DISKUS SINGULAIR XOPENEX HFA Cough and Cold All generically available cough cold medications that require a prescription are on the formulary. Miscellaneous ATROVENT HFA COMBIVENT DUONEB SPIRIVA HANDIHALER THYROID REPLACEMENT levothyroxine includes Levoxyl.
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Tiered co-payments -- which we suspect are behind the lower prescription volumes of the past few years -- will continue to lessen demand, as will a sluggish economy. Sales will be dampened by personal importation and generic introductions. Plus, the slow rate of product introductions in 2001 and 2002 will continue to affect growth. Nine significant products could lose their patent protection in 2003 -- and nearly as many could do so in 2004. Those on the brink this year are: Flovent, an asthma drug by GlaxoSmithKline; Cipro, an anti-infective by Bayer; Plavix, an angina medication by Sanofi; Singulair, an asthma drug by Merck; Flonase, an allergy medication by GlaxoSmithKline; Serzone, an anti-depressant by Bristol-Myers Squibb; Norvasc, a hypertensive by Pfizer; Lotrel, a hypertensive by Novartis; and Nolvadex, a cancer treatment by AstraZeneca. In spite of these challenges, the U.S. pharmaceutical industry still leads the world in solid growth and accounts for over half 50.6 percent ; of the worldwide market -- and there are several encouraging signs for 2003. A large number of drugs have "approvable" letters, and we are guardedly optimistic that more innovative and hydrocodone.
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Dipivefrin hcl . 13 FAMVIR . 8 dipyridamole . 8 FARESTON. 12 disopyramide phosphate . 9 FASLODEX. 12 DITROPAN XL . 11 FAZACLO . 7 dolacet . 5 FELBATOL. 6 dolagesic . 5 felodipine er . 9 dolorex forte. 5 FEMARA. 12 donnaphen. 11 fenofibrate. 9 dopamine hcl . 8 fentanyl patch. 5 DOVONEX . 10 fexofenadine . 9 doxazosin mesylate. 9 FIRST-TESTOSTERONE. 11 doxepin hcl . 6 FLEBOGAMMA . 12 doxycycline hyclate . 5 flecainide acetate . 9 DRITHO-SCALP . 10 FLOMAX. 11 DYGASE . 10 FLOVENT . 9 dylix . 9 FLOXIN OTIC . 13 DYNACIRC . 9 fluconazole . 6 EFFEXOR XR . 6 fludarabine phosphate . 7 EFUDEX . 10 fludrocortsone acetate. 11 ELESTAT . 13 FLUMADINE . 8 ELIDEL. 12 fluocinolone acetonide . 10 EMCYT. 12 fluoride . 13 EMEND . 6 fluorouracil . 7 EMTRIVA . 8 fluoxetine hcl. 6 ENABLEX. 11 fluphenazine decanoate. 7 enalapril. 9 fluphenazine hcl . 7 enalapril hctz. 9 flurbiprofen . 7 ENBREL . 12 flurbiprofen sodium. 13 ENDOCET. 5 flutamide. 12 ENGERIX . 12 fluticasone propionate . 9, 10 enzycap. 10 fluvoxamine maleate. 6 ephedrine sulfate. 8 FORTAZ . 5 EPIPEN . 13 FORTEO . 11 epitol. 6 FOSAMAX . 11 EPIVIR. 8 FOSAMAX D. 11 EPZICOM. 8 furosemide. 9 ERGOLOID MESYLATES . 6 FUZEON. 8 erythromycin . 13 gabapentin. 6 erythromycin ethylsuccinate . 5 GABITRIL. 6 estradiol . 11 GAMMAGARD S D . ethambutol hcl. 7 GAMMAR-P I.V 12 ethosuximide. 6 GAMUNEX . 12 etodolac. 7 ganciclovir . 8 etoposide . 7 GASTROCROM. 11 EVISTA . 11 gemfibrozil . 9 EXELON. 6 GENTAK . 5 EXJADE. 13 gentamicin sulfate. 10 FABRAZYME. 10 GEOCILLIN . 5 FACTIVE. 5 GEODON. 7 famotidine. 11 GLEEVEC . 7 H1099 EL644 25606A26606 Page 17 Employer Groups.
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| In some areas of the old south as an observer in 1834 put it ; , "The bodies of coloured people exclusively are taken for dissection, because the whites do not like it, and the coloured people cannot resist."[162] An item in a New York newspaper in 1841 under the heading "More Pork for the South": Yesterday morning it was discovered [for the third or fourth time in a single month] that a barrel. being shipped to [a medical school]. contained the bodies of two dead Negroes. To elude suspicion, these bodies were put in salt and brine and packed in the same casks as those in which salted provisions were exported.[163].
Pro bono care: David Krier, MD, examines a patient during a volunteer medical mission to Copan, Honduras. "Whenever I've volunteered, I've always come back feeling recharged, " he says. "It helps you remember why you went to medical school or nursing school in the first place." Because Krier feels strongly about making volunteer opportunities feasible for busy professionals, he has designed CPR's medical brigades to be of reasonable duration ranging from one to two weeks ; with built-in opportunities for sightseeing, so that each "working vacation" includes a recreational as well as altruistic component. To make volunteering even more attractive, CPR welcomes people of every religious persuasion, and spouses and children are encouraged to come along. By combining work and play, CPR and other volunteering organizations allow medical professionals to rekindle their passion for medicine and possibly avoid career burnout, one of the major occupational hazards of the field. To measure CPR's effectiveness on preventing burnout, Krier is collaborating with George Fox University in a longitudinal study of program participants. Although the study will not be completed for at least a year, initial results are promising. "Over 50 percent of the first-timers who participate with us say they're planning for a second trip within six months of their return, " says Krier, because foovent 110mcg.
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The pharmacist to determine its suitability for the patient. Pharmacists must ensure that the patient receives sufficient information and advice to enable the safe and effective use of the medicine." The chairman continued: "it has repeatedly been regarded as commonplace that in the event of an unusually large or apparently erroneous or unclear prescription it is incumbent on the pharmacist to query that prescription with the prescriber, under the pain of disciplinary penalty in the event of a failure to do so and a mishap occurring, for instance, flovent 50.
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USA The USA reported five per cent turnover growth in the year and this business represents 52 per cent of total pharmaceutical turnover. Advair maintained its strong growth with sales of 1, 235 million driving the overall respiratory growth of 21 per cent. However, this adversely affected sales of its constituent products, Floveent and Serevent, which both showed declines. Flonase indicated for the treatment of perennial rhinitis grew strongly by 22 per cent. Sales growth of three per cent in the central nervous system products included sales of Wellbutrin up 18 per cent, reflecting the performance of the new once a day formulation Wellbutrin XL. Paxil sales declined nine per cent due to the launch of generic paroxetine in September 2003. GlaxoSmithKline's innovative new product Paxil CR, increased its share of total Paxil prescriptions branded and generic ; since the generic launch from 33 per cent to 37 per cent. Paxil CR sales in 2003 were 387 million. Sales in the anti-virals therapeutic area grew four per cent with HIV led by a strong performance of Trizivir up 20 per cent, which partially drew sales from its constituent products. Valtrex, for herpes, grew 26 per cent driven by the FDA approval for the reduced risk of transmission of genital herpes. Sales of Avandia increased by 20 per cent, benefiting from the launch of Avandamet in November 2002. Anti-bacterial sales declined 41 per cent as a result of generic competition that began in the third quarter 2002. Coreg sales increased 28 per cent reflecting the benefit from recent data that showed a highly significant statistical difference in survival between Coreg and metopropol in patients with heart failure. Europe The discussion of individual market performance in the Europe region is on a `turnover created basis' rather than a `turnover invoiced basis'; see pages 64 to 65 for further details. Europe region contributed 28 per cent of pharmaceutical turnover. Although overall turnover growth in the region was only two per cent, good growth was recorded in Italy and Central and Eastern Europe, but government healthcare reforms, including pricing and reimbursement restrictions, adversely affected turnover in France, Spain and Germany. Seretide, GlaxoSmithKline's largest selling product in Europe, reported notable growth in France, Italy and the UK, although this was partly offset by expected declines in Serevent and Flixotide. Trizivir showed strong growth in all of the major markets in the region. The decline in sales of the herpes franchise was mainly as a result of generic competition for Zovirax partially offset by patients switching to the newer Valtrex product. OTC medicines Analgesics Dermatological Gastro-intestinal Respiratory tract Smoking control Natural wellness support Oral care Nutritional healthcare International An eight per cent turnover growth in the International region reflected a mixture of good growth in the Middle East and Africa, Canada, Japan and Asia Pacific. Latin America also grew strongly as Mexico rebounded following poor economic conditions and a re-alignment of wholesaler stock levels in 2002. Overall International growth was driven by Seretide, Seroxat Paxil and Avandia, partly offset by declines in Zantac and Zovirax. The Asia Pacific area grew due to the performance of Seretide and Avandia. Strong growth in a number of markets was partly offset by a decline of one per cent in the largest market, Australia, reflecting reduced sales of Zyban, Zantac and the older antibiotics. The growth in Japan reflected strong growth of Paxil, Serevent and Valtrex partly offset by the declines of Zovirax, Zantac, and government price reductions. The Middle East and Africa area followed the trends of most other markets with growth in Seretide, Avandia, and vaccines. In Canada growth was driven by Seretide and Avandia. Consumer Healthcare sales.
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Dr. Young-Nam Cha Professor, Inha Univ., Korea ; Dr. Kan Chiba Professor, Chiba Univ., Japan ; Dr. Soo Young Choi Director General, NITR, KFDA, Korea ; Dr. Jae-Soon Eun Professor, Woosuk Univ., Korea 2005 President The Korean Society of Applied Pharmacology ; Dr. Zhuohan Hu Professor, Shanghai Univ., P.R. China ; Dr. Jin-Ding Huang Professor, Nat'l Cheng Kung Univ., Japan ; Dr. John Miners Professor, Flinders Univ. Australia Chairman SAC, ISSX ; Dr. Emi Nakashima Professor, Kyoritsu College of Pharmacy, Japan Finance Committee ISSX ; Dr. Yuichi Sugiyama Professor, Univ. of Tokyo, Japan President, ISSX 2006 ; Dr. Ikumi Tamai Professor, Tokyo Univ. of Science, Japan ; Dr. Krongtong Yoovathaworn Professor, Mahidol Univ., Thailand ; Dr. Hong-Hao Zhou Professor, Central South Univ., P.R. China.
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