| Treatment Group: Paroxetine Adverse event: Epistaxis Nose Bleed ; This 9-year-old white female was a participant in the trial of BRL-29060 701, which was conducted in children and adolescents with major depressive disorder MDD ; . The patient entered the study with no significant previous medical history reported, but a previous surgical history of bilateral inguinal hernia repair and umbilical hernia repair. Current medical history includes asthma and allergy to penicillin. Psychiatric history measured by K-SADS-PL interview ; includes current MDD with an onset of July 2000. No other psychiatric disorders were identified. No previous or concomitant medications were reported. The patient was randomized to the paroxetine regimen and took the first dose of paroxetine on 05 October 2000. The patient began treatment at a dose of 10 mg day and was titrated up, in 10 mg week increments, to the highest dose of 30 mg day on 20 October 2000. On 20 October 2000 Day 16 ; , while at a dose level of 30 mg, the patient experienced moderately severe epistaxis that resolved within 4 days. No treatment was given for this non-serious event that was considered by the investigator to be related to treatment with study medication. This event resulted in withdrawal of the patient from study. The patient discontinued study medication on 21 October 2000 Day 17 ; . The patient also experienced a mild infection scabies ; on 05 October 2000 Day 1 ; that resolved within 22 days, reportedly without treatment. The investigator considered the scabies to be unrelated to treatment with study medication. The patient was started on buspirone HCl BuSpar ; for major depressive disorder beginning 6 days after withdrawal from the study.
For Dental and Upper Respiratory Procedures: Oral: Amoxicillin 50 mg kg max 2 gm ; one hour prior to procedure. Oral, if penicillin allergic: Clindamycin 20 mg kg max 600 mg ; or cephalexin 50 mg kg max 2 gm ; or azithromycin clarithromycin 15 mg kg max 500 mg ; one hour before procedure. IV IM: Ampicillin 50 mg kg max 2 gm ; 30 minutes before procedure IV IM, if penicillin allergic: Clindamycin 20 mg kg max 600 mg ; or cefazolin 25 mg kg max 1 gm ; 30 minutes before procedure. For Gastrointestinal and Genitourinary Procedures: High-Risk Patients: Ampicillin 50 mg kg max 2 gm ; IV plus gentamicin 1.5 mg kg max 120 mg ; IV IM within 30 minutes before starting procedure; then ampicillin 25 mg kg max 1 gm ; IV amoxicillin 25 mg kg max 1 gm ; PO six hours later. High-Risk Patients Allergic to Penicillins: Vancomycin 20 mg kg max 1 gm ; IV over 1-2 hours plus gentamicin 1.5 mg kg max 120 mg ; IV IM - complete injections infusion within 30 minutes before starting procedure. Moderate-Risk Patients: Amoxicillin 50 mg kg max 2 gm ; PO one hour before procedure or ampicillin 50 mg kg max 2 gm ; IV within 30 minutes before starting procedure. Moderate-Risk Patients Allergic to Penicillins: Vancomycin 20 mg kg max 1 gm ; IV over 1 hour; complete infusion within 30 minutes of starting procedure.
Ach year in the United States, a primary complaint of sore throat accounts for an estimated 7.3 million physician visits by children and 6.7 million visits by adults.1, 2 According to recent nationwide surveys, antibiotics were prescribed at 53% of visits by children and 73% of visits by adults for sore throat, 1, 2 even though acute pharyngotonsillitis due to group A -hemolytic streptococcus GABHS ; warranting such therapy would likely be present in only 15% to 30% of cases in children and 5% to 10% of cases in adults.3 Clearly, antibiotics continue to be overprescribed for acute pharyngitis, suggesting that clinicians continue to rely on clinical criteria when making the diagnosis and are underutilizing rapid antigen detection tests RADTs ; . Of equal concern are recent reports of steadily increasing bacteriologic treatment failures with oral penicillin V, which currently may be at least 35% in children and 15% in adults.4, 5 New evidence suggests that the ability of some strains of GABHS to resist antibiotic treatment may depend on an intracellular niche in pharyngotonsillar cells.6, 7 Because penicillins.
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Explanation of the Accounts Receivable Columns If a provider has negative balances of different types or negative balances created at different times, each negative balance will be listed in a different line. REASON CODE DESCRIPTION This is the description of the Financial Reason Code. For example: Third Party Recovery. ORIGINAL BALANCE The original amount or starting balance ; for any particular financial reason. CURRENT BALANCE The current amount owed to Medicaid after the cycle recoupments, if any, were applied ; . This balance may be equal to or less than the original balance. RECOUPMENT % AMOUNT The deduction recoupment ; scheduled for each cycle. Total Amount Due the State This amount is the sum of all the Current Balances listed above, for example, tetracycline penicillin.
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Table I. Distribution of complications in two groups of patients. Complication Wound infection Abscess Total Group I 2 5.7 % ; 0 0 % ; 2 5.7 % ; Group II 4 13.3 % ; 1 3.3 % ; 5 16.6.
Ampicillin, ceftiofur, gentamicin, neomycin, sulfas, tetracycline, trimethoprim- sulfa + Staphylococcus aureus Arthritis, septicemia Penicillin, tetracycline, trimethoprim- sulfa a Legend: + , 50% resistant isolates; + , lC-50%; + , ~10%; f. uncertain; -, resistance absent; based on the literature, clinical observations following treatment, and laboratory observations Salmonellosis 1 and phenergan.
5. European issues EUCAST breakpoints for penicillins and macrolides. Under discussion. 6. NEQAS No major issues. There will be a NEQAS user group meeting on 7 December 2007 that will concentrate on antibiotic-related topics. 7. Questions and answers relating to the BSAC method No major issues. 8. Any other business a. Amoxicillin ampicillin MIC BPs for H. influenzae. An enquiry arose from a poster from the respiratory surveillance of resistance survey. The poster reported resistance rates of co-amoxiclav 12%, ampicillin 13% and amoxicillin 28%. Ampicillin and amoxicillin have similar activity, so the discrepancy in resistance rates is large. BSAC resistance surveillance data for the last few years indicate technical variation with MICs shifting up one dilution, resulting in false!
Elanda s.c. -- Zaklad Produkcji 17 01 07 rodkw Farmaceutycznych Eldex-Medical Eldex-Medical P.P.H. Eldex-Medical", Wiry 2 10 06 and plavix.
While most drugs require oxidative metabolism to be converted into polar metabolites as a necessary step in their elimination, the final route of elimination is via the kidneys.
Increased concerns regarding risks to public health resulting from the use of antimicrobial growth promoters indicate that it is essential to have a systematic approach towards replacing growth-promoting antimicrobials with safer non-antimicrobial alternatives. Currently, most developed nations, with the notable exception of the United States and Canada, have banned the subtherapeutic use of penicillin and tetracycline.72 In addition, in December 1998, the agricultural ministers of the European Union banned the subtherapeutic agricultural uses of bacitracin, spiramycin, virginiamycin, and tylosin. Along with the antibiotics that already were banned by the EU, this completed the ban of all medically important antibiotics. Prior to that ban, Sweden banned the use of any antibiotic for growth promotion; Denmark banned the subtherapeutic use of virginiamycin; Finland banned the subtherapeutic use of tylosin and spiramycin.73, 74 To prevent resistance to antibiotics useful in treating animal disease from developing, Finland proposed that any antibiotic used in veterinary medicine for therapeutic purposes should not also be approved for use as a subtherapeutic additive in feed.75 A 1998 report of the Economic and Social Committee of the European Communities also supported limits on agricultural uses of antibiotics.76 It stated and plendil.
Benzathine benzylpenicillin also known as a donor.
Pegademase bovine, 25 IU Pegaptanib sodium, 0.3 mg Pegaspargase, per single dose vial Penicill8n G Procaine, Aqueous, up to 600, 000 units Peniicllin G Potassium, up to 600, 000 units Penicililn G Benzathine and Penicilllin Procaine, 600, 000 units Penic9llin G Benzathine and Penicillin Procaine, up to 1, 200, 000 units Pen. G Benzathine, up to 600, 000 units Penicillin G Benzathine, up to 1, 200, 000 units Penicillin G Benzathine, up to 2, 400, 000 units Penicillin G Benzathine and Penicillin Procaine, up to 2, 4000, 000 units Pentamidine isethionate, 300 mg Pentastarch, 10% solution, 100 ml Pentazocine HCL, up to 30mg Pentobarbital Sodium, per 50 mg Pentostatin, per 10 mg Permapen, up to 600, 000 units Perphenazine, up to 5 mg Persantine IV, per 10 mg Pfizerpen, up to 600, 000 units Phenergan, up to 50 mg Phenobarbital Sodium, up to 120 mg Phentolamine Mesylate, up to 5 mg Phenylephrine HCL, up to 1 ml Phenytoin Sodium, 50 mg Phytonadione, 1 mg. Piperacillin Sodium tazobactam Sodium, 1 Gram 0.125 Grams 1.125 ; Pitocin, up to 10 units Platinol, 10 mg vial Platinol, 50 mg vial Plicamycin, 2500 mcg Polycillin-N, 500 mg Potassium chloride, per 2 meq Pralidoxime Chloride, up to 1 gm Prednisolone Acetate, up to 1 ml Pregnyl, 1000 USP units Premarin, per 25 mg Priscoline HCL, up to 25 mg Primaxin, per 250 mg. Procainamide HCL, up to 1 gm Prochlorperazine, up to 10 mg Prolastin, 500 mg. Prolixin Decanoate, up to 25 mg Promazine HCL , up to 25 mg Promethazine HCL, up to 50 mg Pronestyl, up to 1 gm Propanolol HCl, up to 1 mg and potassium!
Longer term side effects of AMPRENAVIR can include: increase in the sugar and fat cholesterol, triglyceride ; levels in your blood abnormal body fat distribution increase in waist and breast size and thinning of the face, arms and legs ; Consult your doctor or pharmacist if you have these side effects. Do not stop the medication before you talk to them, for example, penicillin alcohol.
Fleming, recognized the extreme importance of being able to mass-produce an effective penicillin and pravachol.
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PBMC or CSF mononuclear cells were isolated from heparinized blood by centrifugation on Ficoll-Hypaque Pharmacia ; . The medium used throughout was RPMI 1640 Invitrogen Life Technologies ; supplemented with 10% heat-inactivated pooled human AB serum, 2 mM L-glutamine, 20 mM HEPES, 100 U ml penicillin, 100 g ml streptomycin, 5 10 5 M 2-ME. PBMC or CSF cells were washed in complete medium and incubated with FITC-labeled anti-CD8 mAb and PE-labeled pentamers 10 l ; , washed, and analyzed by flow cytometry on a FACSCalibur analyzer. Viable lymphocytes were gated by forward and side scatter, and analysis was performed on 100, 000 acquired events for each sample. HLA-A2 pentamer complexes loaded with the M. tuberculosis Ag85A epitope GLPVEYLQV, the 16-kDa epitope GILTVSVAV, and the ESAT-6 epitope AMASTEGNV were purchased from ProImmune. To assess the phenotype of pentamer T cells, cells were stained with allophycocyanin-labeled anti-CCR7 mAb and PE-Cy5-labeled anti-CD45RA mAb all from BD Biosciences ; in incubation buffer PBS containing 1% FCS and 0.1% sodium azide ; for 30 min at 4C. Cells were then washed twice in PBS with 1% FCS and analyzed by flow cytometry. To study expression of other cell surface markers, four-color FACS analysis was performed on PBMC upon staining with PE-labeled pentamers, allophycocyanin-labeled anti-CCR7 mAb, PE-Cy5labeled anti-CD45RA mAb, and FITC-labeled anti-CD62L or FITC-labeled anti-CD27 or FITC-labeled anti-CD28 or FITC-labeled anti-CD57 mAbs all from BD Biosciences and prednisone!
Drug interactions for alternative version including pharmacokinetic data, see alternative section xxiv.
The most common side effects of the drug include leg cramps, breast tenderness, and vaginal infections and premarin.
| Is erythromycin a form of penicillinPossible that the imidazole group of the histidine residue located at the recognition site is protonated by the -amino group of the dipeptides and aminocephalosporins but not by the peptide-like drugs that do not have an -amino group. The -amino group of the substrates might interact with the imidazole ring of the histidine residue of peptide transporters by proton binding. It is noted that these results were observed for PEPT1 and PEPT2 in a similar manner, which suggests that the DEPCsensitive histidine residue plays the same role in both transporters. Among the substrates examined that had an -amino group, only cyclacillin did not show the preventive effect against the DEPC inactivation. This may be due to the structure of cyclacillin. Cyclacillin has an -carbon group as part of its cyclohexane ring; therefore, the cyclohexane ring may interfere with the -amino group-histidine interaction. Nevertheless, cyclacillin was recognized by PEPT1 at a relatively high affinity 14, 19 ; . A possible explanation is that the hydrophobic NH2-terminal side chain of cyclacillin interacts with the peptide transporters instead of the -amino group-histidine interaction. As reported by Daniel et al. 20 ; , the marked hydrophobicity of the NH2terminal side chain of aminopenicillins increased the affinity to.
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Novartis has been advertising its eye drop product Zaditor or Z-Drops. This is the first advertising for the brand following the establishment of Novartis Ophthalmics in 1999. The advertising runs on television until the end of May and in the press to cover the allergy season. Novartis is looking to create awareness of the problem and visit the doctor to obtain a prescription. The company sees it as low interest for the doctor and is therefore looking for consumers to recognise the problem and identify with it personally. The press advertising uses the copyline "Some people will try anything to stop their eyes from itching" and uses an image of the eyeballs being rinsed under the tap. The commercial also shows the eyeballs being removed to be washed.
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MEASURE IP OWNER1 NUMERATOR DENOMINATOR Loracarbef Minocycline Ofloxacin Penicillin VK Penicillin G Sparfloxacin Sulfisoxazole Tetracycline Trimethoprim Trimethoprim-sulfamethoxazol Note: If the episode occurred on July 1 of the year prior to the measurement year, look 30 days prior to the start of the Intake Period June1-30 ; to check for negative medication history. Step 4: This measure examines one eligible episode per patient. Select the first eligible episode for each patient during the measurement Intake period that meets all criteria for inclusion in the denominator. The denominator patients for inclusion ; : A sample should be determined using the most accurate data available in the settings in which the measure will be implemented. The measure developer recommends that in most settings office visit claims see list of codes ; or other codified encounter data should be used to identify patients who have had at least one office visit in the prior 12 ; months from which a purposeful sample random, consecutive retrospective or prospective from a specific date ; can then be chosen for the denominator. In other uses of the EXCLUSIONS DATA SOURCE and prevacid.
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CONFIDENTIALITY . 46 RECORD KEEPING . 46 DRUG AND ALCOHOL AWARENESS TRAINING. 46.
On September 29, 2005, the Company signed an exclusive worldwide licensing agreement with Atrium for the use of TAFA93 and ISA247 with drug eluting medical devices. These devices deliver drug locally to treat cardiovascular disorders and assist in soft tissue repair e.g., stents and surgical meshes, respectively ; . As such, Atrium's implantable product line utilizes the non-systemic applications of these two drugs. The Company received a licensing fee of $3.49 million US$3.0 million ; and will receive further milestone and royalty payments once the drug eluting devices are commercialized. Isotechnika will supply the drug compounds on a cost plus 10% basis. Atrium will conduct and be financially responsible for all development costs of the medical device product program. Isotechnika has met its financial obligations with respect to the development of ISA247 under the terms of this agreement. Isotechnika was required to complete a Phase 1b multiple ascending dose human clinical trial and related development work for TAFA93 under the terms of this agreement. The Company completed the Phase 1b trial in 2006 and expects to complete the remainder of the required development work in 2007. Collaboration agreement with F. Hoffmann-La Roche and Hoffmann-La Roche Inc. On April 9, 2002, the Company entered into a strategic collaboration "Collaboration Agreement" ; with F. Hoffmann-La Roche and Hoffmann-La Roche Inc. hereinafter collectively referred to as "Roche" ; for the global co-development and commercialization of ISA247. Under the terms of this Collaboration Agreement, Roche had the worldwide exclusive right to manufacture market and sell the ISA247 product for all indications. The terms of the Collaboration Agreement provided for equity investments, milestone payments and sales based payments. In addition, Roche was responsible for 70% and Isotechnika was responsible for 30% of eligible development costs incurred by both Roche and Isotechnika as defined in the Collaboration Agreement. On April 19, 2004, Isotechnika and Roche amended the original Collaboration Agreement, whereby Isotechnika reacquired the worldwide rights for all non-transplant indications of ISA247, including psoriasis. Isotechnika can therefore develop any of the non-transplant indications of ISA247 without assistance from Roche or choose to market and license any of the non-transplant indications of ISA247 with any third party. Under the amended terms of the Collaboration Agreement, Roche has an option to develop and commercialize ISA247 for transplant indications up to the completion of the Phase 2b kidney transplant trial. Upon the completion of this Phase 2b kidney transplant trial Roche will have 90 days to exercise its option. To exercise this option, Roche will pay an option exercise fee of US$75 million, make future.
And occasionally a narrow 1 mm. wide ; crescent of superficial corneal edema just anterior to the margin of the conjunctival bleb. Neither the conjunctival hemorrhages nor the crescent of corneal edema were noted in any animal 24 hours after the subconjunctival dicloxacillin injection. Histologic section of representative eyes enucleated 48 hours after subconjunctival injection revealed only scattered inflammatory cells with slight edema of the episcleral tissues. Necrosis of conjunctiva, episclera, or sclera was not observed in any specimen. Comment The sensitivity of various common bacteria to dicloxacillin is shown in Table II. A concentration of 0.50 xg per milliliter would inhibit growth of most gram-positive cocci including penicillinase producing Staphylococcus aureus. This latter organism has been implicated as the pathogen responsible for many cases of postoperative endophthalmitis.10"10 Dicloxacillin levels in secondary aqueous humor far exceed those needed to inhibit growth of Staphylococcus aureus. Such extremely high antibiotic levels are present in secondary aqueous humor for at least 4 hours following a single intravenous injection. An entirely satisfactory growth-inhibiting concentration of 0.53 j.ig per milliliter is still present at 8 hours. We are unaware of previous studies dealing with the intraocular penetration of dicloxacillin. Oxacillin, another member of the isoxazolyl pneicillin family, required an intravenous dose of 75 mg. per kilogram to produce therapeutically useful levels in secondary aqueous humor of rabbits. Like dicloxacillin, oxacillin did not cross the intact blood-aqueous humor barrier.17 In another report, oxacillin was found not to penetrate the intact human blood-aqueous humor barrier Oxacillin, which is 93 per cent bound to plasma protein, failed to penetrate into secondary aqueous humor of rabbits until a dose of 75 mg. per kilogram was given.17 Dicloxacillin, which is slightly.
TABLE OF CONTENTS 1. 2. 3. MAIN FINDINGS OBJECTIVES LEGAL BASIS PRODUCTION AND PERCENTAGE OF TARGETED SAMPLES FOR BOVINES, PIGS, SHEEP AND GOATS, HORSES PRODUCTION AND PERCENTAGE OF TARGETED SAMPLES FOR POULTRY HORMONES CORTICOSTEROIDS BETA-AGONISTS PROHIBITED SUBSTANCES A6 ; ANTIBACTERIALS B1 ; VETERINARY MEDICINAL PRODUCTS B2 ; OTHER SUBSTANCES AND EVIRONMENTAL CONTAMINANTS B3 ; OVERALL DISTRIBUTION OF NON-COMPLIANT IN THE EU AQUACULTURE MILK EGGS RABBIT MEAT FARMED GAME WILD GAME HONEY, because penicillin antivirus.
Tion; however, the -lactamases produced by M catarrhalis are different from those produced by H influenzae. As a result, some agents eg, cefpodoxime proxetil, cefuroxime axetil ; are less active against M catarrhalis than H influenzae see Table 3 ; . M catarrhalis is also intrinsically resistant to trimethoprim.86, 89 Prevalence of Antimicrobial Resistance Among Isolates of S pneumoniae Isolates of S pneumoniae with penicillin MICs 0.06 g mL are defined as penicillin-susceptible, whereas penicillin-intermediate strains have penicillin MICs of 0.12 to 1.0 g mL, and penicillin-resistant isolates of S pneumoniae have a penicillin MIC of 2 g mL. The latter two groups are often referred to as "penicillin-nonsusceptible, " and the clinical significance of these varies with different -lactams as will be discussed. Drug-resistant S pneumoniae DRSP ; connotes strains with penicillin MICs of 0.12 g mL and or resistance to other classes of antibiotics. Multidrug-resistant S pneumoniae are defined as organisms resistant to three or more classes of antibiotics. The increasing prevalence of isolates of S pneumoniae that are penicillin nonsusceptible has been and pepcid.
Gbola amusa, a medical doctor and financial analyst for sanford bernstein & company, said his company was not forecasting sales of alli because of uncertainties and the fact that the revenue would be split by glaxo and roche.
The Bronsted-Lowry theory of acids and bases defines an acid as a substance, charged or uncharged that is capable of donating a proton: and a base is a substance charged or uncharged that is capable of accepting a proton from an acid. Acidic substances only behave as acids in the presence of a base, and a basic substance only behaves as a base when in the presence of an acid. Most drugs are weakly acidic or weakly basic when dissolved in water and their relative strengths are associated with their tendency to give up and take on protons. Hydrochloric acid is a stronger acid than acetic when dissolved in water since it more readily dissociates, giving up its proton. However the strength of an acid varies in different solvents, for example hydrochloric acid is a weak acid in glacial acetic acid and acetic acid is a strong acid in liquid ammonia. Consequently the strength of an acid depends not only on its ability to give up a proton but also on the ability of the solvent to accept it. This is referred to as the basic strength of the solvent. The mechanism by which an acid transfers a proton to a base is called dissociation or ionization. Acids and bases are crudely classified as strong or weak depending on the completeness of the ionization process extent of ionization ; . Strong acids are completely ionized in aqueous solution for example HNO3, HCl, HClO4 and H2SO4 and weak acids are partially ionized in water e.g., H3BO3, HCN, H2S. The same holds true for strong and weak bases respectively. By the Bronsted Lowry definition, most pharmaceuticals can be considered as being weak acids or weak bases. Examples of acidic drugs include: amobarbital, aspirin, ibuprofen, penicillins. Atropine, codeine, epinephrine.
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