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Lexchin J, Bero LA, Djulbegovic B, Clark O. Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ 2003; 326: 1167-70. Bekelman JE, Li Y, Gross CP. Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 2003; 289: 45465. Als-Nielsen B, Chen W, Gluud C, Kjaergard LL. Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events? JAMA 2003; 290: 921-8. The Cochrane Collaboration. The Cochrane Collaboration--principles. cochrane docs tenprinciples accessed 18 Sept 2006 ; . 5 Jadad AR, Cook DJ, Jones A, Klassen TP, Tugwell P, Moher M, et al. Methodology and reports of systematic reviews and meta-analyses: a comparison of Cochrane reviews with articles published in paper-based journals. JAMA 1998; 280: 278-80. Jadad AR, Moher M, Browman GP, Booker L, Sigouin C, Fuentes M, et al. Systematic reviews and meta-analyses on treatment of asthma: critical evaluation. BMJ 2000; 320: 537-40. Oxman AD, Guyatt GH. Guidelines for reading literature reviews. Can Med Assoc J 1988; 138: 697-703. Jadad AR, McQuay HJ. Meta-analyses to evaluate analgesic interventions: a systematic qualitative review of their methodology. J Clin Epidemiol 1996; 49: 235-43. Oxman AD, Guyatt GH. Validation of an index of the quality of review articles. J Clin Epidemiol 1991; 44: 1271-8. Berlin JA. Does blinding of readers affect the results of meta-analyses? Lancet 1997; 350: 185-6, for instance, prinivil 20.
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General anesthesia prior to treatment of anterior mediastinal masses in pediatric cancer patients. Anesthesiology 1990; 72: 991-5. Shamberger RC, Holzman RS, Griscom NT, Tarbell NJ, Weinstein HJ. CT quantitation of tracheal cross-sectional area as a guide to the surgical and anesthetic management of children with anterior mediastinal masses. J Pediatr Surg 1991; 26: 138-42. Pio AJ, Weiss DR, Hellman S. Mediastinal Hodgkin's disease: a possible danger for intubation. Int J Radiat Oncol BiolPhys 1976; 1: 415-9. Hanley JA. If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA 1983; 249: 1743-5. Description: Zymine Liquid is an alcohol-free, sugar-free red syrup for oral administration having an apple odor and flavor. EACH TEASPOON 5mL ; CONTAINS: Triprolidine Hydrochloride 1.25mg CLINICAL PHARMACOLOGY: Triprolidine provides symptomatic relief of conditions believed to depend wholly or partly upon the release of histamine. Triprolidine hydrochloride antagonizes the effects of histamine by competing for histamine-1 H1 ; receptor sites. The serum half-life for triprolidine is 3 to 3.3 hours. INDICATIONS AND USAGE: Zymine Liquid is indicated for the symptomatic relief of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, and mild uncomplicated allergic skin manifestations of urticaria and angioedema. CONTRAINDICATIONS: Zymine Liquid is contraindicated in individuals who have a known hypersensitivity to triprolidine HCl or any of its ingredients. WARNINGS: Antihistamines should be used in considerable caution in patients with glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy and bladder neck obstruction. PRECAUTIONS: DRUG INTERACTIONS: MAO inhibitors and tricyclic antidepressants may prolong and intensify the anticholinergic effects of antihistamines. Concomitant use of antihistamines with tricyclic antidepressants, barbiturates and other CNS depressants may have an additive effect. Antihistamines should be used with considerable caution in patients with history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease and hypertension. CARCINOGENESIS, MUTAGENESIS, AND IMPAIRMENT OF FERTILITY: No adequate or well controlled studies have been conducted to determine whether the components of Zymine Liquid have a potential for carcinogenesis, mutagenesis, or impairment of fertility. PREGNANCY: Pregnancy Category C: Animal reproduction studies have not been conducted with this product. It is not known whether it can cause fetal harm when administered to a pregnant woman or can effect reproduction capacity. This product should not be administered to pregnant women. NURSING MOTHERS: Due to the possible passage of the ingredients into breast milk, this product should not be given to nursing mothers. ADVERSE REACTIONS: Possible side effects of antihistamines are drowsiness, dry mouth, anorexia, nausea, vomiting, headache, dizziness, nervousness, blurred vision, polyuria, heartburn, dysuria, urinary retention and very rarely, dermatitis. OVERDOSAGE: SIGNS AND SYMPTOMS: Manifestations of antihistamine overdosage may vary from CNS depression sedation, apnea, cardiovascular collapse ; to stimulation insomnia, hallucinations, tremors, or convulsions ; . Other signs and symptoms may be dizziness, tinnitus, blurred vision and hypertension. Stimulation is particularly likely in children, as are atropine-like signs and symptoms. TREATMENT: Treatment of the signs and symptoms of overdosage is symptomatic and supportive. The patient should be induced to vomit, even if emesis has occurred spontaneously. Pharmacologic vomiting by the administration of ipecac syrup is a preferred method, however, vomiting should not be induced in patients with impaired consciousness. Precautions against aspiration must be taken, especially in infants and children. Following emesis, any drug remaining in the stomach may be absorbed by activated charcoal administered as a slurry with water. DOSAGE AND ADMINISTRATION: Zymine Liquid is administered orally as follows: Adults: 2 teaspoonfuls every 4 to 6 hours not to exceed 4 doses in a 24 hour period. Children 6 - 12 years of age: 1 teaspoonful every 4 to 6 hours not to exceed 4 doses in a 24 hour period. Children 4 - 6 years of age: 3 4 teaspoonful every 4 to 6 hours not to exceed 4 doses in a 24 hour period. Children 2 - 4 years of age: 1 2 teaspoonful every 4 to 6 hours not to exceed 4 doses in a 24 hour period. Children 4 months - 2 years: 1 4 teaspoonful every 4 to 6 hours not to exceed 4 doses in a 24 hour period. HOW SUPPLIED: 16 fluid ounce bottles NDC # 67204-32016 and 15ml bottles NDC # 67204-320-15 KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN. IN CASE OF ACCIDENTAL OVERDOSAGE, CONTACT A POISON CONTROL CENTER AND SEEK PROFESSIONAL ASSISTANCE IMMEDIATELY. Store between 59-86F 15-30C ; . DISPENSE IN TIGHT, LIGHT- RESISTANT CONTAINERS WITH CHILD-RESISTANT CLOSURES AS DEFINED IN THE USP NF. Rx ONLY Manufactured for: Memphis, TN 38134 Rev. 7 05.

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