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Q. How should intravenous vitamin K phytomenadione ; be administered when used to reverse the effects of anticoagulation? The intravenous preparation of vitamin K phytomenadione ; is Konakion MM 10mg in 1ml. A dose of 1mg to 2mg is usually prescribed to reverse the effects of excessive anticoagulation. This presents a problem because of the small volume involved. One suggestion is that for a dose of 2mg, the 10mg per ml preparation should be diluted to 20ml with glucose 5%. A 2mg dose would then equate to 4ml which can be administered as a slow bolus over 3-5 minutes. The use or dose of vitamin K prescribed may vary locally. Please contact your Ward Pharmacist Pharmacy Department for further advice. Principles of Consolidation The accompanying consolidated financial statements include the accounts of the Company and its significant subsidiaries. Consolidation of the remaining subsidiaries would have had no material effect on the accompanying consolidated financial statements. Sankyo Agro Co., Ltd. and Sankyo Lifetech Co., Ltd., which were carved out from the Company and newly established in April 2003, have been included in the scope of consolidation effective the year ended March 31, 2004. Sankyo Trading Co., Ltd., which had been a consolidated subsidiary of the Company until the year ended March 31, 2004, has been excluded from the scope of consolidation effective the current period due to sale of the Company's entire shares in this company. Investments in unconsolidated subsidiaries and affiliates are stated at cost. If the equity method had been applied to the investments in these companies, this would have had no material effect on the accompanying consolidated financial statements. All significant intercompany accounts and transactions have been eliminated in consolidation. The excess of cost over the underlying net assets at the dates of the investments in the subsidiaries is being amortized over a five-year period, for instance, theo drug. Such as reverse isolation and treatment with G-CSF or granulocytemacrophage colonystimulating factor GM-CSF ; , antibiotics and antifungals as appropriate, may be required. The CPMS data indicate an increased risk of agranulocytosis with increasing age and Asian ethnicity Munro et al, 1999 ; . Additionally, some authors al, have suggested an increased risk in women Alvir & Lieberman, 1994 ; , although this was not seen in the UK CPMS cohort, and in people of Ashkenazi Jewish descent with the haplotype HLA-B38, DR4, DQw3 Lieberman et al, 1990 ; . Concomitant al, treatment with other drugs reported to cause leucopenia may also increase the risk of agranulocytosis Idanpaan-Heikkila et Idanpaan-Heikkila al, 1977; Povlsen et al, 1985; Lindstrom, al, al, Lindstrom, 1988; Gerson et al, 1991; Gerson & al. Ruling out serious causes health- or life-threatening causes of seizures should first be ruled out and ventolin. 16 This is highly individualized and no specific guidelines are available. We follow an adaptation of the protocol recommended by JJ Volpe3. We usually try to discontinue all medication at discharge if clinical examination is normal, irrespective of etiology and EEG. If neurological examination is persistently abnormal at discharge, AED is continued and the baby is reassessed at 1 month. If the baby is normal on examination and seizure free at 1 month, phenobarbitone is discontinued over 2 weeks. If neurological assessment is not normal, an EEG is obtained. If EEG is not overtly paroxysmal, AED are tapered and stopped. If EEG is overtly abnormal, the infant is reassessed in the same manner at 3 months and then 3 monthly till 1 year of age!
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A Medical Quiz has been organized at Diamond APICON-2005 to be held at Hotel Renaissance, Mumbai on 24th January 2005. There will be 4 teams of 3 participants each. Team entries consisting of 3 participants will be perferred. However, if 4 team entries are not received, then single entries will be entertained and lots will form teams. If the entries will be more, then selection of team will be done by a Screening test Lots. Decision of formation of teams will rest with the undersigned. There are attractive prizes for winners. Those who want to participate are requested to send their entries to the undersigned by 31st October 2004. The Medical Quiz is only for the Registered Delegates of Diamond APICON-2005. Dr. SB Gupta, President Elect and Chairman Scientific Committee Diamond APICON-2005. 18, Greylands, Railway Officers' Flats, New Marine Lines, Mumbai 400 020. Tel. : 022-22624556; Fax : 022-22651044; Cell : 09821364565 09821638617; E mail : sbgupta vsnl ; Website : apiindia. 2 7 Recommendations to the ICCS Board 1 ; 2 ; 3 ; Formation of an industry advisory body to facilitate dissemination of ICCS research initiatives and to bolster participation by key stakeholders Invitation to acknowledged experts and prominent clinicians researchers to join ICCS Research Committee Dissemination of Terms of Reference to ICCS membership and collation of individuals and centres willing to participate in collaborative initiatives Selection of 4 key areas of research. ICCS approach to relevant industry and presentation of terms of reference and collaborative research proposals. The following RCT research PICO parameters Population, Intervention, Comparator, and Outcomes ; are proposed: a. OAB EUS dyssynergia, botox A B injections, placebo injections n of 1 cohort, number of incontinent episodes symptom score b. OAB, M3 selective anti-muscarinic solifenacin darifenacin propiverine ; , placebo, number of incontinent episodes and quality of life score c. Voiding dysfunction, -1d selective blocker, placebo drug, PK and PD data and change in symptom scores d. Nocturnal polyuria monosymptomatic NE, non-steroidal antiinflammatory drug, placebo drug, change in number of dry nights e. Dysfunctional elimination syndrome, epidemiology, normative paediatric cohort, epidemiological profile and diagnostic criteria f. Neurogenic detrusor dysfunction, implantable neuromodulator, n of 1 cohort, post void residual volume, voids per day and number of incontinent episodes Approach FDA and its European equivalent to facilitate studies that analyze pharmacokinetics, and efficacy of new drugs for pediatric use and differin.
A Special Election Period is provided for certain situations, such as: the Medicare Prescription Drug Plan organization breaks its contract with an employer individual or does not renew its contract with CMS Centers for Medicare and Medicaid Services ; , or other exceptional conditions determined by CMS. During this time, an individual may change to a different Medicare Prescription Drug Plan.
To make a bequest of cash or property to The Society for Progressive Supranuclear Palsy, your will or supplemental codicil should state: "I give and bequeath to The Society for Supranuclear Palsy, a non-profit corporation, organized under the laws of the State of Maryland and having its main office at Woodholme Medical Building, Suite 515, 1838 Greene Tree Road, Baltimore MD 21208, the sum of $ or % of the residue, rest and remainder of my estate to be used for the general purposes and mission of the organization." A bequest to the Society is fully deductible for estate tax purposes. To learn more about opportunities for giving, consult your attorney, accountant, estate planner or call the Society for PSP office, 1-800-457-4777 and eldepryl. Training practitioners MEDS started stoking ARVs in July 2001, but finally slowed down on realising that majority of the health workers were not competent in the use of these agents. In August 2001, MEDS conducted the first 3-day training for doctors in the management of HIV AIDS and the use of ARVs. In collaboration with Ecumenical Pharmaceutical Network EPN ; and funding from ActionAid Kenya, 123 doctors and 60 clinical officers from CHAK and KEC health facilities were trained in the use of ARVs. MEDS has a policy of not supplying ARVs to any institution which does not have a member of staff trained in the use of these drugs. Generic ARVs MEDS negotiated with the Ministry of Health to be allowed to import generic ARVs in the country before their registration process was completed. Permission was granted.

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C. Boyden Gray Wilmer, Cutler & Pickering ; , "Citizen Petition" to the U.S. Food and Drug Administration on behalf of Bristol-Myers Squibb, December 26, 2001. Nicholas deB. Katzenbach, "Memorandum to the United States Congress Proposed Amendment to the Hatch-Waxman Act, " November 29, 2001. Laurence Tribe, "Memorandum to the United States Congress, Subject: Constitutional Analysis of H.R. 2887's Proposed Amednment to HatchWaxman Act Eliminating Three-Year Clinical Studies Exclusivity Period." Undated and feldene. Symptoms can range from mild to severe and may come and go over time. Other symptoms of lupus include chest pain, hair loss, anemia a decrease in red blood cells ; , mouth ulcers, and pale or purple fingers and toes from cold and stress. Some people also experience headaches, dizziness, depression, confusion, or seizures. New symptoms may continue to appear years after the initial diagnosis, and different symptoms can occur at different times. In some people with lupus, only one system of the body, such as the skin or joints, is affected. Other people experience symptoms in many parts of their body. Just how seriously a body system is affected varies from person to person. The following systems in the body also can be affected by lupus. Kidneys: Inflammation of the kidneys nephritis ; can impair their ability to get rid of waste products and other toxins from the body effectively. There is usually no pain associated with kidney involvement, although some patients may notice swelling in their ankles. Most often, the only indication of kidney disease is an abnormal urine or blood test. Because the kidneys are so important to overall health, lupus affecting the kidneys generally requires intensive drug treatment to prevent permanent damage. Lungs: Some people with lupus develop pleuritis, an inflammation of the lining of the chest cavity that causes chest pain, particularly with breathing. Patients with lupus also may get pneumonia. Central nervous system: In some patients, lupus affects the brain or central nervous system. This can cause headaches, dizziness, memory disturbances, vision problems, seizures, stroke, or changes in behavior. Blood vessels: Blood vessels may become inflamed vasculitis ; , affecting the way blood circulates through the body. The inflammation may be mild and may not require treatment or may be severe and require immediate attention. Blood: People with lupus may develop anemia, leukopenia a decreased number of white blood cells ; , or thrombocytopenia a decrease in the number of platelets in the blood, which assist in clotting ; . Some people with lupus may have an increased risk for blood clots. Heart: In some people with lupus, inflammation can occur in the heart itself myocarditis and endocarditis ; or the membrane that surrounds it pericarditis ; , causing chest pains or other symptoms. Lupus can also increase the risk of atherosclerosis hardening of the arteries, because theo dur sr.

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Focused on African Americans, indicating the need for additional research in Hispanic populations. The Food and Drug Administration FDA ; has long requested race and ethnicity data on subjects in certain clinical trials. A recent FDA draft guidance for industry notes that some differences in response to pharmaceuticals have been observed in racially and ethnically distinct subgroups within the U.S. population. The guidance recommends the use of standard race and ethnicity categories for data collection.70 Uniform categories will be helpful in evaluating potential differences among ethnic and racial subgroups in the safety and efficacy of pharmaceuticals and will help to further ensure ethnic and racial diversity in clinical trials of new drugs and frusemide.

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Background: Normal pregnancy is associated with substantial changes in the hemostatic system. The increase of numerous coagulation factors FI, FII, FVII, FVIII, FX ; as well as a gradually decrease of total and free protein S lead to a hypercoaguable state. Indeed, F1 + 2 and TAT increase progressively during pregnancy. Despite these elevated procoagulative factors and signs of clotting activation, in the only study measuring thrombin generation by a manual method Eichinger reports an unchanged endogenous thrombin potential ETP ; during pregnancy. With the calibrated automated thrombography CAT ; by Hemker a method was developed that facilitates the analysis of thrombin generation in patient cohorts. Subjects: Blood was collected from 135 pregnant women in the 7th to 41th gestational week. The test persons were clinically well, had no pregnancy associated diseases, no history of previous venous thromboembolism, and no treatment with antithrombotic drugs. Methods: Thrombin generation was measured using a slow fluorogenic substrate by means of calibrated automated thrombography. In addition we measured prothrombin, free protein S, TFPI, PAI-I, TAT and F1 + F2. Obtained data were correlated with the gestational weeks and regression analyses were calculated. Results: The gestational weeks correlated significantly with the endogenous thrombin potential ETP ; and peak thrombin generation. In addition, prothrombin correlated significantly with ETP and peak. Furthermore a significant negative correlation between gestational weeks and protein S, a significant positive correlation between gestational weeks and PAI-I as well as with TFPI and the markers of prothrombin activation TAT, F1 + F2 ; existed. ETP and peak did not correlate with markers of prothrombin activation. Conclusion: Thrombin generation significantly increases with gestational weeks but does not correlate with markers of prothrombin activation. Whether parameters of thrombin generation or prothrombin activation correlate better with clinical disease remains to be shown, for instance, theo dur 300 mg. Synopsis With the planned introduction of the revised service for the provision of domiciliary oxygen, PCT chief executives are asked to review the number and provision of oxygen 'sets' in their locality. Oxygen sets are integral to the delivery of oxygen gas from cylinders to patients. These are currently provided by community pharmacists and are loaned to patients for the duration of their need for oxygen therapy. The purchase of additional oxygen sets should be limited to what is absolutely necessary to meet the requirements of the current service. Details at doh.gov oxygen oxygensets and keflex.

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To this date, Cuba remains the only country in the region without an EU cooperation agreement. After the Cuban authorities expelled several European politicians and journalists planning to attend the Asamblea para Promover la Sociedad Civil Assembly to Promote Civil Society ; in May 2005 in Havana, the Council of the EU "categorically condemned Cuba`s unacceptable attitude towards foreign parliamentarians and journalists" but reaffirmed the Common Position and "reiterated its willingness to maintain a constructive dialogue with the Cuban authorities."4 The measures of 5 June 2003 remained suspended and the date of the next evaluation of the Common Position was set for June 2006. Despite the EU`s willingness to enter into dialogue, the position of the. Before taking erythromycin, tell your doctor if you are taking digoxin lanoxin disopyramide norpace warfarin coumadin theophylline theo-dur, theobid, and others midazolam versed ; or triazolam halcion ergotamine ercaf, cafergot, ergostat, ergomar ; or dihydroergotamine e and nifedipine. It is especially important to check with your doctor before combining nizoral with the following: alcoholic beverages antacids such as di-gel, maalox, mylanta, and others anticoagulants such as coumadin, dicumarol, and others anti-ulcer medications such as axid, pepcid, tagamet, and zantac astemizole hismanal ; cisapride propulsid ; cyclosporine sandimmune, neoral ; digoxin lanoxin ; drugs that relieve spasms, such as donnatal isoniazid nydrazid ; methylprednisolone medrol ; midazolam versed ; oral diabetes drugs such as diabinese and micronase phenytoin dilantin ; rifampin rifadin, rifamate, and rimactane ; tacrolimus prograf ; terfenadine seldane ; theophyllines slo-phyllin, theo-dur, others ; triazolam halcion ; special information if you are pregnant or breastfeeding if you are pregnant or plan to become pregnant, inform your doctor immediately. Current Pharmacogenomics, 2003, Vol. 1, No. 1 3 and reminyl and theo-dur, for example, drug dur. Wishful thinking adds detail, constrains prediction, and thereby creates a burden of improbability. What of the civil engineer who hopes a bridge won't fall? Should the engineer argue that bridges in general are not likely to fall? But Nature itself does not rationalize reasons why bridges should not fall. Rather the civil engineer overcomes the burden of improbability through specific choice guided by specific understanding. A civil engineer starts by desiring a bridge; then uses a rigorous theory to select a bridge design which supports cars; then builds a real-world bridge whose structure reflects the calculated design; and thus the real-world structure supports cars. Thus achieving harmony of predicted positive results and actual positive results. 5: Friendly AI It would be a very good thing if humanity knew how to choose into existence a powerful optimization process with a particular target. Or in more colloquial terms, it would be nice if we knew how to build a nice AI. To describe the field of knowledge needed to address that challenge, I have proposed the term "Friendly AI". In addition to referring to a body of technique, "Friendly AI" might also refer to the product of technique - an AI created with specified motivations. When I use the term Friendly in either sense, I capitalize it to avoid confusion with the intuitive sense of "friendly". One common reaction I encounter is for people to immediately declare that Friendly AI is an impossibility, because any sufficiently powerful AI will be able to modify its own source code to break any constraints placed upon it. The first flaw you should notice is a Giant Cheesecake Fallacy. Any AI with free access to its own source would, in principle, possess the ability to modify its own source code in a way that changed the AI's optimization target. This does not imply the AI has the motive to change its own motives. I would not knowingly swallow a pill that made me enjoy committing murder, because currently I prefer that my fellow humans not die. But what if I try to modify myself, and make a mistake? When computer engineers prove a chip valid - a good idea if the chip has 155 million transistors and you can't issue a patch afterward - the engineers use human-guided, machine-verified formal proof. The glorious thing about formal mathematical proof, is that a proof of ten billion steps is just as reliable as a proof of ten steps. But human beings are not trustworthy to peer over a purported proof of ten billion steps; we have too high a chance of missing an error. And present-day theorem-proving techniques are not smart enough to design and prove an entire computer chip on their own - current algorithms undergo an exponential explosion in the search space. Human mathematicians can prove theorems far more complex than modern theorem-provers can handle, without being defeated by exponential explosion. But human mathematics is informal and unreliable; occasionally someone discovers a flaw in a previously accepted informal proof. The upshot is that human engineers guide a theorem-prover through the intermediate steps of a proof. The human chooses the next. 3.1 3.2 3.3 Global . Europe . North America . Asia, Africa, Australia, and Latin America . Japan . China . Finland . Contract research organizations CRO ; . Development of the pharmaceutical market, role of generics and selegiline. Alcohol place are often ulo drug effects main vector mouthpiece.

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Stress appears to be the biggest negative influence on modern man's sexual desires. The research showed that relationship problems and a sense of not measuring up to partners' expectations, sexual or otherwise, greatly reduce modern man's sexual pleasure. The threat to sexual desire is largely a psychological and emotional one. The demands of relationships and their associated problems appear to dominate men's concerns. Intimate or family issues are far more likely to have an impact than professional ones. Physical illness does of course play a role, with 28 per cent citing a health problem as a reason, but it is not as significant as stress or relationship problems. Our research shows common issues running through all nationalities, with other issues indicating economic pressures, family and cultural influences. Stress Stress was the number one reason given for loss of sexual desire, with nearly half of all men citing this as a reason. Stress was the factor that seemed most to affect the sex lives of 40 to year olds who were married, co-habiting or divorced men. Single and widowed men were less likely to name this as a reason for reduced desire.
Wosinska M, Huckman R. Generic dispensing and substitution in mail and retail pharmacies. Health Affairs. Web Exclusive. July 28, 2004. Available at: : content.healthaffairs cgi reprint hlthaff.w4.409v1?maxtoshow &HITS 10&hits 10&RESULTFORMAT &author1 wosinska&andorexactfulltext and&searchid 1109282481483 4094&stored search &FIRSTINDEX 0&resourcetype 1&journalcode healthaff. Accessed February 25, 2005. CALCIUM SUPPLEMENTATION AND OR VITAMIN D IN OSTEOPOROSIS - MYTH OR REALITY? R Prince University Of Western Australia, School Of Medicine & Pharmacology, Nedlands, WA One of the central problems in nutrition science is to determine the optimal intake of nutrients to prevent disease in an individual taking into account their genetic, environmental and disease status. In the first part of the 20th century the principal nutritional focus was on the, for example, theo dur sr. Figure 5: Measures of metabolic control. A: HbA1c of eight insulin-independent subjects over 3 years post-transplant. B: Continuous glucose monitoring--3 days of blood glucose values subject 4. C and D: Oral glucose tolerance testing at 1 and 2 years post-transplant Table 4: Comparison of supplemental infusions Firts and second infusions Recipient 1 6 7 MEAN SD Total IEQ 1 379 919 Total IEQ kg 17 556 18 Days off Ins 258 184 396 Third Infusion IEQ 464 400 802 IEQ kg 6276 15 738 Pre-infusion Ins requirements U Day ; 30 15 14 Day ; 0.41 0.28 0.23 Days Ins indep 348 + 303 453 + 280 292 16 Current ins U Day ; 44 5 10 Day ; 0.59 0.08 0.12 and ventolin. [A] claimed invention is unpatentable if the differences between it and the prior art are `such that the subject matter as a whole would have been obvious at the time the invention was made to a person having ordinary skill in the art.'" Alza Corp. v. Mylan Labs., Inc., F.3d , No. 06-1019, 2006 U.S. App. LEXIS 22616, at * 4 Fed. Cir. Sept. 6, 2006 ; quoting 35 U.S.C. 103 a . Obviousness is a question of law. Id. at * 4-5. Its resolution depends on four underlying factual inquiries, the so-called Graham5 factors: "` 1 ; the scope and content of the prior art; 2 ; the level of ordinary skill in the prior art; 3 ; the differences between the claimed invention and the prior art; and 4 ; objective evidence of nonobviousness.'" Id. at * 5 quoting In re Dembiczak, 175 F.3d 994, 998 Fed. Cir. 1999 . 1. The Scope and Content of the Prior Art. Dietary Supplements Dietary supplements, ranging from essential nutrients to herbal remedies and sports products, have become a multi-billion dollar business during the past decade. Besides the traditional multi-vitamin and mineral supplements designed to correct or prevent nutrient deficiencies or reduce the risk of chronic diseases, there is a growing list of ergogenic products substances that promise to boost physical performance ; to tempt both weekend and professional warriors. Some Air Force personnel may take supplements because they believe they cannot or do not consume enough food to meet their nutritional needs. Or they may believe supplements provide extra nutrients or give a performance advantage that food alone cannot provide. Although some persons may need or benefit from dietary supplements in some situations or at certain times, the routine use of supplements is not worthwhile for most personnel. Simply following a sensible diet see the previous section on the Dietary Guidelines for Americans ; will provide adequate nutrition to meet the needs of almost all military personnel. Although a few dietary supplements may possess qualities that might enhance health status or sport performance, many, if not most, do not live up to their marketing hype. Supplements are not regulated and do not fall under the same strict formulation and production guidelines as drugs. Manufacturers of dietary supplements do not have to prove they are safe and effective before putting them on the market. Also, those who benefit from their sales often distort or exaggerate the research findings or overlook negative effects. There is very little research on the safety of taking even beneficial supplements for a long time. In addition, the effect of simultaneously taking multiple supplements is unknown, as is the effect of taking supplements in very hot or very cold climates. Also unknown is the highest safe level of intake for many supplements. Vitamins A and D, iron, zinc, and selenium are especially toxic in high doses, while large amounts of vitamin B6, niacin, and many other nutrients have harmful side effects. Table 9. RDAs and Tolerable Upper Intake Levels for selected vitamins and minerals Recommended Dietary Allowance RDA ; Or Adequate Intake A 700 g female ; a 900 g male ; a D 200 IU 5g ; a Iron 18 mg female ; a 8 mg male ; a Zinc 8 mg female ; a 11 mg male ; a Selenium 55 ga B6 1.5 mga Niacin 14 mg female ; a 16 mg male ; a a RDA for males and females ages 19 50. b For males and females ages 19 70. Vitamin Mineral Tolerable Upper Intake Level 3000 g b 3000 g b 2000 IU 50g ; b 45 mgb 45 mgb 40 mgb 40 mgb 400 gb 100 mgb 35 mgb 35 mgb. Edward hariss faq q: do i need to pay for the delivery.
A message from Mental Health & Addictions aving a healthy and happy Christmas is about celebrating with family and friends, and often our celebrations involve alcohol. We wish you the best for the season and offer you a few simple reminders for a safe and happy holiday: Drink responsibly. Pace yourself, and have a glass of water or fruit juice after every alcoholic beverage. Know your limit. A 12-ounce can of beer, a 1-ounce glass of spirits, and a 5-ounce glass of wine all contain about the same amount of alcohol. Alcohol is eliminated at a rate of about one drink per hour, but the effect alcohol has on you is also influenced by the amount of food you have eaten; whether you are tired or overly fatigued; and by your weight, age, and metabolism. Have a bite to eat. Protein-packed foods like cheese and meats are better at reducing the rate of absorption of alcohol, while salty foods will increase your thirst. Have a designated driver. If you're planning a night out be sure to make arrangements for a safe ride home. Be a responsible, pro-active host. If you are hosting a party, serve a variety of snacks and non-alcoholic beverage options. Measure drinks, assign a responsible bartender, and don't rush to refill glasses. Stop serving alcohol an hour before the party is to end. Plan ahead, and make sure your guests use designated drivers or stay the night. If you or someone you know needs help, call our Interlock Employee and Family Assistance Program at 1800-663-9099. They provide after hours emergency toll-free direct telephone access to a fully qualified Masters level counsellor. Or contact your family physician, walk-in clinic, or find a service in your community using the ServiceDirectory on our website at interiorhealth . Wishing you a safe, healthy, and happy holiday season.
57 ; Abstract: The invention relates to the use of a substance for the diagnostic detection of Sgk, especially Sgk1 and or Sgk3, and or PKB and or Nedd, especially Nedd4-2, and to the use of active ingredients which influence glucose transport for treating diseases associated with disturbed glucose transport, and for fattening animals. The invention also relates to a diagnosis kit and a pharmaceutical composition comprising an active quantity of at least one active ingredient which influences glucose transport. The invention further relates to a method for producing transgenic animals, for instance, theo dur sa.
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